Increased Elastin Content in the Vaginal Wall of Postmenopausal Women with Pelvic Organ Prolapse
نویسنده
چکیده
Hypothesis / aims of study Changes in elastin content have been linked to the pathophysiology of pelvic organ prolapse (POP), however it is unclear whether the elastin content is increased [1] or decreased [2,3]. Such discrepancies could be attributed to differences in biopsy site, kind of analysis and/or patient population. Our study is the first to perform an extended biochemical analysis of different elastin features in tissues from the anterior vaginal wall of postmenopausal Caucasian women with and without POP. We aimed to compare elastin content, cross-linking, post-translational modification, and enzymatic degradation profiles of the (normal) precervical region and the prolapsed anterior vaginal wall tissues of women with POP. These data were compared to tissues from the precervical anterior vaginal wall of controls without prolapse to identify features specific to POP in the different parameters evaluated.
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Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content
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